Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrastructural changes in somatotropic cells induced by anemic or hypoxic hypoxia.

Acta physiologica latino americana·1982
Same author

Foetal haemopoiesis during the hepatic period. I. Relation between in vitro liver organogenesis and erythropoietic function.

The Anatomical record·1981
Same author

Foetal haemopoiesis during the hepatic period. III. Erythroid cell kinetics.

Acta physiologica latino americana·1980
Same author

Foetal haemopoiesis during the hepatic period. II. Topographic histology.

Journal of embryology and experimental morphology·1979
Same author

Ultrastructure of STH cells of the pars distalis of hepatectomized mice.

Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948)·1971
Same journal

Effects of a single-dose denosumab on glucose and lipid homeostasis in young infertile men.

Endocrine·2026
Same journal

Ultrasound-guided thermal ablation for papillary thyroid microcarcinoma with calcifications: short-term imaging outcomes.

Endocrine·2026
Same journal

Diabetic gastroparesis: pathophysiology and impact on insulin timing choices.

Endocrine·2026
Same journal

Liquid biopsies for BRAF V600E assessment and monitoring in anaplastic thyroid carcinoma: a real-world study of a tertiary cancer center.

Endocrine·2026
Same journal

Interpreting the TIR 3B nomogram as a rule-in rather than rule-out tool.

Endocrine·2026
Same journal

Clinical and laboratory characteristics of pediatric patients diagnosed with thyroid hormone resistance: A single-center experience.

Endocrine·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

Pituitary physiological and ultrastructural changes during aging.

A C Nessi1, G De Hoz, C Tanoira

  • 1Universidad CAECE, Avda de Mayo 1400, 1085, Buenos Aires, Argentina.

Endocrine
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Aging reduces pituitary hormone production due to intrinsic pituitary gland changes, not just external factors. Aged mice show decreased growth hormone (GH) and thyroid-stimulating hormone (TSH) cell function and increased cell death.

More Related Videos

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Related Experiment Videos

Last Updated: Jun 6, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
15:26

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Area of Science:

  • Gerontology
  • Endocrinology
  • Cell Biology

Background:

  • Aging is associated with decreased pituitary hormone production.
  • The exact cause, whether external (e.g., dopaminergic failure) or internal (pituitary gland dysfunction), is debated.

Purpose of the Study:

  • To investigate the cellular mechanisms underlying reduced pituitary hormone production in aged animals.
  • To determine if pituitary gland aging contributes to decreased growth hormone (GH) and thyroid-stimulating hormone (TSH) release.

Main Methods:

  • CFW mice of varying ages (2, 6, 12, 18 months) were treated with L-Dopa.
  • Pituitary glands were examined using electron microscopy.
  • Digital image analysis quantified secretory granules and organelle kinetics.

Main Results:

  • Aged GH and TSH cells showed reduced responsiveness to L-Dopa stimulation compared to young cells.
  • The proportion of fully functional GH and TSH cells decreased significantly with age (98% in young vs. 65.7% in aged).
  • Aged cells exhibited progressive degenerative changes, including apoptosis, indicating intrinsic pituitary pathology.

Conclusions:

  • Reduced pituitary hormone production in aging is not solely due to extrapituitary factors.
  • Intrinsic changes within the pituitary gland itself, including cellular degeneration and apoptosis, significantly contribute to age-related hormone decline.