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Growth responses to patterned GH delivery.

R G Clark1, D Mortensen, L M Carlsson

  • 1Endocrine Research Department, Genentech, Inc, 390 Pt. San Bruno Blvd., 94080, South San Francisco, California, USA.

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|December 15, 2010
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Summary
This summary is machine-generated.

Intermittent recombinant human growth hormone (rhGH) injections best support whole-body growth, while continuous rhGH infusions promote differential organ growth. This highlights varied therapeutic responses based on rhGH administration patterns.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Growth Hormone Research

Background:

  • Recombinant human growth hormone (rhGH) is crucial for growth and metabolic processes.
  • Understanding optimal rhGH administration is key for effective therapeutic outcomes.
  • Previous studies show varied responses to different rhGH delivery methods.

Purpose of the Study:

  • To investigate the impact of different rhGH administration patterns (injections vs. infusions) on growth parameters.
  • To assess the effects on serum GH binding protein (GHBP) and insulin-like growth factor-1 (IGF-1) levels.
  • To compare rhGH efficacy in hypophysectomized (Hx) and GH-deficient dwarf (dw/dw) rat models.

Main Methods:

  • Administered rhGH via subcutaneous injections (1-2 daily) or continuous infusions in Hx and dw/dw rats.
  • Administered recombinant human insulin-like growth factor-1 (rhlGF-1) via subcutaneous infusion.
  • Monitored body weight, tibial epiphyseal plate width, organ weights, and serum GHBP/IGF-1 levels.

Main Results:

  • All rhGH regimens increased body weight and organ growth dose-dependently in Hx rats.
  • Twice-daily rhGH injections yielded superior whole-body growth compared to continuous infusions.
  • Continuous rhGH infusions were more potent for tibial growth and significantly increased thymus weight.

Conclusions:

  • Intermittent rhGH administration (injections) is optimal for overall body weight gain.
  • Continuous rhGH administration (infusions) preferentially stimulates specific organ growth, potentially via sustained IGF-1 levels.
  • Administration pattern significantly influences rhGH efficacy and physiological response.