Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Behavioral Genetics and Its Designs

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

Case Studies

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Trihybrid Crosses

Trihybrid Crosses

Trihybrid Crosses
Some of Mendel’s crosses examined three pairs of contrasting characteristics. Such a cross is called a trihybrid cross. A trihybrid cross is a combination of three individual monohybrid crosses. For example, plant height (tall vs. short), seed shape (round vs. wrinkled), and seed color (yellow vs. green).
The F1 generation plants of a trihybrid cross are heterozygous for all three traits and produce eight gametes. Upon self-fertilization, these gametes have an equal chance to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

International network of twin registries (INTR): building a platform for international collaboration.

Twin research and human genetics : the official journal of the International Society for Twin Studies·2014

Same author

Genetic influences on alcohol use behaviors have diverging developmental trajectories: a prospective study among male and female twins.

Alcoholism, clinical and experimental research·2014

Same author

Defining the role of common variation in the genomic and biological architecture of adult human height.

Nature genetics·2014

Same author

All-cause and disease-specific mortality among male, former elite athletes: an average 50-year follow-up.

British journal of sports medicine·2014

Same author

Cohort Profile: The National Academy of Sciences-National Research Council Twin Registry (NAS-NRC Twin Registry).

International journal of epidemiology·2014

Same author

Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies.

Cephalalgia : an international journal of headache·2014

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Advanced methods in twin studies.

Jaakko Kaprio¹, Karri Silventoinen

¹Department of Public Health and Institute of Molecular Medicine, University of Helsinki & National Institute for Health and Welfare, Helsinki, Finland.

Methods in Molecular Biology (Clifton, N.J.)

|December 15, 2010

Summary

This summary is machine-generated.

Twin studies, enhanced by recent statistical and data collection advances, now explore genetic and environmental influences on traits and diseases. Modern methods integrate specific genetic data and environmental factors for comprehensive analysis.

More Related Videos

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

Related Experiment Videos

Last Updated: Jun 6, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas

Published on: September 5, 2011

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Using Cholesky Decomposition to Explore Individual Differences in Longitudinal Relations between Reading Skills

Published on: September 17, 2019

Area of Science:

Behavioral Genetics
Quantitative Genetics
Human Genetics

Background:

Twin studies have historically estimated heritability since the early 1900s.
Recent statistical advancements and data collection have significantly broadened twin study applications.
The field now integrates complex genetic and environmental interactions.

Purpose of the Study:

To review advanced twin study designs for investigating genetic and environmental contributions to traits and diseases.
To highlight the integration of specific genetic variants and measured environmental factors.
To illustrate these methodologies with examples from anthropometric trait research.

Main Methods:

Review of contemporary twin study designs.
Latent genetic influence modeling.
Inclusion of specific genetic variants and measured environmental factors.
Analysis of gene-environment interactions.

Main Results:

Advanced twin study models allow for detailed investigation of genetic and environmental influences.
Integration of specific genetic and environmental data provides a more nuanced understanding.
Illustrative examples demonstrate the application of these sophisticated approaches.

Conclusions:

Modern twin studies offer powerful tools for dissecting the etiology of traits and diseases.
The incorporation of molecular genetics and environmental data enhances etiological research.
These refined methods advance our understanding of complex trait development.