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Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

Protein Folding

Protein Folding

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Related Experiment Video

Updated: Jun 6, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Protein structure alignment based on internal coordinates.

Yue-Feng Shen¹, Bo Li, Zhi-Ping Liu

¹Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing.

Interdisciplinary Sciences, Computational Life Sciences

|December 15, 2010

Summary

This summary is machine-generated.

A new protein structure alignment method, SABIC, uses internal coordinates for multi-alignments. It outperforms existing algorithms like DALI and CE in detecting protein structural classifications and significance.

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Area of Science:

Computational Biology
Structural Bioinformatics
Protein Science

Background:

Protein structure alignment is crucial for understanding protein evolution, function, and folding.
Existing methods have limitations in accurately identifying structural similarities and classifications.

Purpose of the Study:

Introduce a novel protein structure alignment method, SABIC.
Improve the accuracy and reliability of protein structure comparison and classification.

Main Methods:

Developed SABIC based on internal coordinates (bond lengths, angles, torsion angles).
Generated multi-alignments to capture diverse structural similarities.
Introduced mQ-score for alignment quality assessment and statistical significance (P-value) calculation.

Main Results:

SABIC demonstrated superior performance compared to DALI, CE, and SSM on benchmark datasets.
Achieved consistent improvements in detecting protein structural classifications using the mQ-score.
Enabled simultaneous calculation of alignment statistical significance.

Conclusions:

SABIC offers a robust and accurate approach for protein structure alignment.
The method enhances the identification of evolutionary relationships and functional similarities.
SABIC software is available for broader research applications.