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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

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Updated: Jun 6, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Structural bioinformatics: deriving biological insights from protein structures.

Nagasuma Chandra1, Praveen Anand, Kalidas Yeturu

  • 1Bioinformatics Centre, Indian Institute of Science, Bangalore. nchandra@serc.iisc.ernet.in

Interdisciplinary Sciences, Computational Life Sciences
|December 15, 2010
PubMed
Summary
This summary is machine-generated.

Structural bioinformatics deciphers biological insights from protein structures, offering a high-resolution understanding of life. This approach aids in inferring protein function and mechanisms, with applications in drug discovery.

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Last Updated: Jun 6, 2026

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16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Area of Science:

  • Structural bioinformatics
  • Structural biology
  • Computational biology

Background:

  • Protein structures provide high-resolution biological insights.
  • Inferring protein function from 3D structures is crucial for understanding biological processes.
  • Structural data interpretation is key in modern biology.

Purpose of the Study:

  • To provide an overview of structural bioinformatics.
  • To highlight recent advances in the field.
  • To explore applications of structural bioinformatics in drug discovery.

Main Methods:

  • Analysis of protein structures.
  • Comparison and classification of protein structures.
  • Function transfer based on structural similarity.

Main Results:

  • Protein structure space is more conserved than sequence space.
  • Structural bioinformatics offers deeper mechanistic insights than sequence-based methods.
  • Structural insights are valuable for understanding biological events.

Conclusions:

  • Structural bioinformatics is essential for deciphering biological insights from protein data.
  • The field provides a powerful approach to understanding protein function and mechanisms.
  • Structural bioinformatics plays a significant role in advancing drug discovery efforts.