Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.

PLoS genetics·2026
Same author

Heritability of Alzheimer's disease-related plasma biomarkers in the Amish population.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning.

bioRxiv : the preprint server for biology·2026
Same author

The role of microRNAs in cardiovascular disease associated with the consumption of ultra-processed foods: a comprehensive review.

Frontiers in nutrition·2026
Same author

Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7-associated Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Related Experiment Video

Updated: Jun 6, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Inflammation, stem cells and atherosclerosis genetics.

Pascal J Goldschmidt-Clermont1, David M Seo, Liyong Wang

  • 1University of Miami Leonard M Miller School of Medicine, Department of Medicine, Rosenstiel Medical Science Building, 1600 NW 10th Avenue, Miami, FL 33136, USA. pgoldschmidt@med.miami.edu

Current Opinion in Molecular Therapeutics
|December 15, 2010
PubMed
Summary

Aging accelerates atherosclerosis by exhausting endothelial progenitor cells (EPCs) essential for arterial repair. New genetic data reveals inflammation and stem cell genes linked to this aging-risk mechanism.

More Related Videos

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

Related Experiment Videos

Last Updated: Jun 6, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

Area of Science:

  • Cardiovascular Biology
  • Genetics
  • Aging Research

Background:

  • Atherosclerosis is a leading cause of human mortality, with aging as its primary risk factor.
  • The precise aging-risk mechanism underlying atherosclerosis remains poorly understood.
  • A novel hypothesis suggests impaired endothelial progenitor cell (EPC)-dependent arterial repair contributes to disease development.

Purpose of the Study:

  • To review recent genetic findings related to atherosclerosis susceptibility.
  • To explore the role of arterial homeostasis and EPC function in aging-related atherosclerosis.
  • To highlight genetic links between inflammation, immune response, stem cells, and arterial repair.

Main Methods:

  • Review of genetic linkage studies and genome-wide association studies (GWAS).
  • Analysis of molecular evidence implicating EPC exhaustion in atherosclerotic lesion formation.
  • Focus on non-biased genetic approaches to identify susceptibility genes.

Main Results:

  • Genetic studies identify genes associated with atherosclerosis susceptibility and thromboembolic disorders.
  • Identified genes are frequently linked to inflammation, immune response, and stem cell regulation.
  • Evidence suggests atherosclerotic lesions may initiate from failed arterial repair rather than solely from injury.

Conclusions:

  • Exhaustion of repair-competent EPCs is a critical factor in age-related atherosclerosis.
  • Genetic factors influencing inflammation and stem cell function play a key role in arterial homeostasis.
  • Understanding these genetic mechanisms offers new insights into atherosclerosis and aging.