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Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Family intervention for schizophrenia.

Fiona Pharoah¹, Jair Mari, John Rathbone

¹South West Community Mental Health Team, Oxford and Buckinghamshire Mental Health NHS Foundation Trust, Apex 550 (Unit 5), The Valley Centre, Gordon Road, High Wycombe, Buckinghamshire, UK, HP13 6EQ.

The Cochrane Database of Systematic Reviews

|December 15, 2010

Summary

This summary is machine-generated.

Family psychosocial interventions significantly reduce relapse rates and hospital admissions for individuals with schizophrenia. These interventions also improve medication adherence and reduce expressed family emotions, benefiting patients and their families.

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Area of Science:

Psychiatry and Mental Health
Clinical Psychology
Family Therapy

Background:

High levels of expressed emotion (criticism, hostility, over-involvement) in families are linked to increased relapse rates in schizophrenia.
Psychosocial interventions aim to reduce these high-expressed emotion levels within families.

Purpose of the Study:

To evaluate the effectiveness of community-based family psychosocial interventions for schizophrenia compared to standard care.

Main Methods:

Systematic review and meta-analysis of 53 randomized controlled trials (RCTs) from the Cochrane Schizophrenia Group Trials Register.
Data extraction and analysis included relative risk (RR) and number needed to treat (NNT) for binary outcomes, and mean differences (MD) for continuous outcomes.

Main Results:

Family intervention significantly decreased relapse frequency (RR 0.55, NNT 7) and hospital admissions (RR 0.78, NNT 8).
Improved medication compliance (RR 0.60, NNT 6) and reduced general social impairment were observed.
No significant effect on care탈퇴 rates; insufficient data on suicide prevention/promotion.

Conclusions:

Family psychosocial interventions show promise in reducing relapse and hospitalizations for schizophrenia patients.
Findings suggest benefits for patients, clinicians, and policymakers.
Methodological quality of included trials was often poor, potentially overestimating treatment effects; further high-quality trials are recommended.