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Effects of ofloxacin on cell-mediated immune response and lymphokine production
A Biglino1, B Forno, A M Pollono
1Institute of Infectious Diseases, University of Torino, Italy.
Abstract:
The effects of orally administered ofloxacin on functional parameters of cell-mediated immunity were investigated in 15 patients with respiratory or urinary tract infections. Mononuclear leucocytes were obtained before administering the drug, 1 h after the first dose, and five days later. The cells were stimulated with lectins, tetanus toxoid and Newcastle Disease virus in order to assess mitogen- and antigen-induced lymphocyte proliferation and production of gamma-interferon, interleukin-2 and alpha-interferon. An increase in proliferative response to pokeweed mitogen and a slight but significant decrease in alpha-interferon production were observed, while other parameters remained unaffected by treatment.
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