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Updated: Jun 6, 2026

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Published on: September 13, 2022

[Flecainide poisoning].

M Doniz Campos¹, G Illodo Miramontes, B Bobillo

¹Servicio de Anestesiología y Reanimación, Hospital Universitario Xeral-Cíes, Vigo. donizmaria@hotmail.com

Revista Espanola De Anestesiologia Y Reanimacion

|December 16, 2010

Summary

This summary is machine-generated.

Flecainide intoxication is rare but dangerous, causing hypotension and arrhythmias. Careful monitoring is crucial, especially in patients with kidney or liver issues, as no antidote exists.

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Area of Science:

Pharmacology
Cardiology
Toxicology

Background:

Flecainide is an antiarrhythmic medication that functions by blocking cardiac sodium channels.
Its mechanism of action impacts phase 0 of the cardiac action potential, affecting conduction and contractility.

Observation:

Flecainide intoxication is uncommon but associated with rapid onset of severe hypotension and cardiac arrhythmias.
The drug's metabolism is significantly impaired in patients with renal or hepatic failure, increasing accumulation risk.

Findings:

Management of flecainide poisoning relies on limited case reports as no specific antidote is available.
The case highlights flecainide prescribing in a patient with resolving sepsis and concurrent renal/hepatic complications.

Implications:

Vigilant clinical, electrocardiographic, and hemodynamic monitoring, alongside plasma level assessment, is imperative when prescribing flecainide.
Caution is advised when administering flecainide to patients with kidney or liver dysfunction; benefits must outweigh risks.