Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

Cirrhosis I: Introduction

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plain language summary of publication of the 96-week results from the PHOTON study: intravitreal aflibercept 8 mg for diabetic macular edema.

Therapeutic advances in ophthalmology·2026

Same author

An examination of the availability and characteristics of social needs data in the electronic health records: a path to social data harmonization and standardization at Johns Hopkins medicine.

JAMIA open·2026

Same author

Intraocular Pressure Outcomes with Intravitreal Aflibercept 8 mg: A 96-Week Pooled Analysis from PULSAR and PHOTON.

Ophthalmology and therapy·2026

Same author

Safety and Biodistribution of Topical Laquinimod, an Immunomodulator Targeting Aryl Hydrocarbon Receptor: The LION Study.

Ophthalmology science·2026

Same author

Impact of Baseline Best-Corrected Visual Acuity on Outcomes with Aflibercept 8 mg in Patients with Diabetic Macular Edema.

Ophthalmology. Retina·2026

Same author

GLP-1 Receptor Agonists: Clinical Considerations and Risk Management for Patients Undergoing Ophthalmic Surgery.

Ophthalmic surgery, lasers & imaging retina·2026

Search research articles

Related Experiment Video

Updated: Jun 6, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Nodular sclerochoroidopathy simulating choroidal malignancy.

Elham Hatef¹, Jianmin Wang, Mohamed Ibrahim

¹Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye

|December 16, 2010

Summary

This summary is machine-generated.

Nodular sclerochoroidopathy, a rare condition, presents with subretinal and choroidal lesions. Early diagnosis and treatment with steroids and mycophenolate mofetil can improve visual acuity and regress lesions.

More Related Videos

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jun 6, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Area of Science:

Ophthalmology
Medical Research

Background:

Nodular sclerochoroidopathy is a rare inflammatory condition affecting the sclera, choroid, and retina.
It can present with multiple subretinal and choroidal yellowish lesions and episcleral nodules.

Observation:

A 55-year-old male presented with a 1.5-year history of subretinal and choroidal lesions and episcleral nodules.
The patient later developed classic features of posterior scleritis, including choroidal and serous retinal detachment.

Findings:

Diagnosis of nodular sclerochoroidopathy was confirmed.
Long-term therapy with corticosteroids and mycophenolate mofetil led to regression of posterior scleritis and nodular lesions.
Significant improvement in visual acuity was observed post-treatment.

Implications:

Nodular sclerochoroidopathy should be considered in the differential diagnosis of patients presenting with subretinal and choroidal lesions.
Distinguishing nodular sclerochoroidopathy from choroidal neoplasms is crucial for appropriate management.
Combined immunosuppressive therapy shows efficacy in managing this condition.