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Updated: Jun 6, 2026
Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Marked differences in Betapapillomavirus DNA and antibody prevalence between patients with psoriasis and those with
M N C de Koning1, M C A Polderman, T Waterboer
1DDL Diagnostic Laboratory, 2275 CX Voorburg, the Netherlands.
Background:
Recent studies revealed that Betapapillomavirus (betaPV) infections are highly prevalent. Skin diseases such as psoriasis, characterized by keratinocyte hyperproliferation, and atopic dermatitis (AD), dominated by cutaneous inflammation, might have an impact on viral life cycle and immune response induction.
Objectives:
To investigate whether betaPV infection is different in psoriasis and AD.
Methods:
Twenty-seven patients with psoriasis and 17 with AD were included for betaPV genotyping using eyebrow hairs, and for seroresponse determination.
Results:
BetaPV DNA was found significantly more often in patients with psoriasis than in those with AD (100% vs. 81%, P=0·022) and the mean number of betaPV types was higher (4·8 vs. 2·1 types, P=0·002). In contrast, the seroprevalence in patients with AD was significantly higher compared with that in patients with psoriasis (88% vs. 56%, P=0·023). Type-specific concordance of serological response to the betaPV type detected in eyebrow hairs was 27% in patients with psoriasis and 47% in those with AD (P=0·019).
Conclusions:
We speculate that the condition of the skin and the immunological state of the patients have an important impact on the life cycle of betaPV.