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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

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Related Experiment Video

Updated: Jun 6, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Neonatal transfusion review.

Steven R Sloan1

  • 1Department of Pathology, Harvard Medical School, Children's Hospital Boston, Boston, MA 02115, USA. steven.sloan@childrens.harvard.edu

Paediatric Anaesthesia
|December 16, 2010
PubMed
Summary
This summary is machine-generated.

Neonatal transfusions require special care due to maternal antibodies and immature immune systems. Irradiation of cellular components prevents graft-versus-host disease but risks hyperkalemia and hypocalcemia in neonates.

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Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

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Last Updated: Jun 6, 2026

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Area of Science:

  • Neonatal Medicine
  • Transfusion Medicine
  • Immunology

Background:

  • Neonates present unique immunological profiles compared to older patients.
  • Maternal antibodies in neonatal plasma affect blood compatibility and testing.
  • Neonates lack antibodies to minor erythrocyte antigens, simplifying certain tests.

Purpose of the Study:

  • To highlight the specific challenges and considerations in neonatal blood transfusions.
  • To discuss the implications of maternal antibodies on transfusion practices.
  • To review risks associated with irradiated blood components and RBC storage.

Main Methods:

  • Review of existing literature on neonatal transfusion practices.
  • Analysis of immunological differences between neonates and adults.
  • Examination of risks associated with irradiated blood components and additives.

Main Results:

  • Neonatal plasma may contain maternal ABO antibodies, complicating compatibility testing.
  • Irradiation of cellular components, while preventing graft-versus-host disease, increases risks of hyperkalemia and hypocalcemia.
  • Storage of red blood cells (RBCs) carries risks of dilutional coagulopathy and additive toxicity.

Conclusions:

  • Neonatal transfusions necessitate tailored approaches due to unique immunological factors.
  • Careful consideration of irradiation effects and storage-related risks is crucial for safe neonatal transfusions.
  • Further research into optimizing transfusion strategies for vulnerable infant populations is warranted.