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Related Experiment Video

Updated: Jun 6, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Update on treatments for premature ejaculation.

W J G Hellstrom¹

¹Department of Urology, Tulane University, New Orleans, LA 70112, USA. whellst@tulane.edu

International Journal of Clinical Practice

|December 16, 2010

Summary

This summary is machine-generated.

New treatments for premature ejaculation (PE) are emerging, offering hope for improved quality of life. These include on-demand therapies like dapoxetine and tramadol, alongside topical anesthetics.

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Treatment of Ejaculatory Duct Obstruction by Seminal Vesiculoscopy Assisted Flow Modification

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Published on: December 8, 2023

Area of Science:

Urology
Sexual Medicine
Pharmacology

Background:

Premature ejaculation (PE) is a condition of global clinical interest.
Current treatment guidelines lack FDA-approved therapies, relying on off-label antidepressants and topical anesthetics with limitations.

Purpose of the Study:

To review current and upcoming treatment options for premature ejaculation (PE).
To highlight novel therapies in development that aim to overcome limitations of existing treatments.

Main Methods:

Review of existing literature and clinical development status of PE treatments.
Analysis of established guidelines and emerging therapeutic agents.

Main Results:

Established treatments include paroxetine, sertraline, fluoxetine, clomipramine, and lidocaine-prilocaine cream, though they have limitations.
Emerging on-demand treatments in advanced development include dapoxetine (SSRI), PSD502 (lidocaine/prilocaine aerosol), and tramadol (opioid).

Conclusions:

Novel, PE-specific therapies are in development, potentially improving treatment efficacy and patient quality of life.
Efficient diagnosis coupled with new on-demand agents is expected to enhance outcomes for individuals with PE.