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Related Experiment Videos

Prostate cancer: post-irradiation incontinence.

N Green1, D Treible, H Wallack

  • 1Division of Radiation Therapy, Valley Presbyterian Hospital, Van Nuys, California.

The Journal of Urology
|August 1, 1990
PubMed
Summary

External irradiation for prostate cancer can cause incontinence. Avoiding transurethral prostatectomy before or after treatment, especially for diagnosis, may reduce this risk. Needle biopsy is preferred for tissue diagnosis.

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Area of Science:

  • Urology
  • Oncology
  • Radiation Oncology

Background:

  • Post-irradiation incontinence is a known complication of prostate cancer treatment.
  • Understanding risk factors is crucial for improving patient outcomes.

Purpose of the Study:

  • To assess factors contributing to post-irradiation incontinence in prostate cancer patients.
  • To identify strategies for minimizing the risk of this complication.

Main Methods:

  • Retrospective review of 272 prostate cancer patients treated with external irradiation between 1976 and 1987.
  • Analysis of patient data including pre-existing incontinence, tumor characteristics, surgical interventions, and post-irradiation incontinence severity.

Main Results:

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  • Overall, 7% of patients developed post-irradiation incontinence.
  • Incontinence was not significantly linked to tumor stage or control.
  • Procedures like transurethral prostatectomy (TURP) before or after irradiation increased incontinence risk compared to needle biopsy.
  • Patients with urinary outlet obstruction treated without pre-irradiation TURP had 0% incontinence.

    • Conclusions:

    • Selective use of transurethral prostatectomy (TURP) is recommended to decrease post-irradiation incontinence risk.
    • Needle biopsy is the preferred method for tissue diagnosis over TURP.
    • Managing urinary outlet obstruction without pre-irradiation TURP, potentially with endocrine therapy, can prevent incontinence.