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Related Experiment Video

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Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms.

Nicolas W Martin¹, Beben Benyamin, Narelle K Hansell

¹Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia. nico.martin@qimr.edu.au

Journal of the American Academy of Child and Adolescent Psychiatry

|December 16, 2010

Summary

This study found no evidence that the FADS2 gene and breast-feeding interact to affect IQ. Apparent breast-feeding effects on IQ may be linked to parental education, not genetics.

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Published on: September 22, 2023

Area of Science:

Genetics
Neuroscience
Human Development

Background:

Previous research suggested an interaction between the FADS2 gene (rs174575) and breast-feeding, potentially influencing IQ.
Specifically, C-allele carriers of rs174575 were reported to have higher IQs when breast-fed compared to formula-fed.

Purpose of the Study:

To investigate the interaction between breast-feeding and FADS2 gene polymorphisms (rs174575) on IQ in an Australian adolescent twin sample.
To examine the influence of other FADS2 polymorphisms (rs1535, rs174583) and maternal FADS2 status on offspring IQ.

Main Methods:

Analyzed data from over 700 families of adolescent twins.
Assessed IQ, breast-feeding history, birth weight, FADS2 polymorphisms (rs174575, rs1535, rs174583), and parental socioeconomic factors.
Controlled for parental education, socioeconomic status, and maternal FADS2 status.

Main Results:

No significant interaction was found between rs174575 genotype and breast-feeding on IQ.
No main effects of FADS2 polymorphisms or breast-feeding on IQ were detected after controlling for parental socioeconomic factors.
Maternal FADS2 status did not influence offspring IQ.

Conclusions:

The study does not support the hypothesis of a FADS2 gene and breast-feeding interaction influencing IQ.
Observed associations between breast-feeding and IQ are likely confounded by parental education and socioeconomic status.
Genetic factors within FADS2 do not appear to directly impact IQ in this cohort.