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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Partners in crime: Genes within an amplicon collude to globally deregulate chromatin in lymphoma

Dong-Joon Min1, Jonathan D Licht

  • 1Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

Cancer Cell
|December 16, 2010
PubMed

Insights

Researchers found two coamplified oncogenes, JAK2 and JMJD2C, in specific lymphomas. Targeting these genes offers a new therapeutic strategy for these B-cell cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Primary mediastinal B-cell lymphoma and Hodgkin lymphoma are aggressive non-Hodgkin lymphomas.
  • The genetic underpinnings of these lymphomas are complex and involve alterations in oncogenes and tumor suppressor genes.

Discussion:

  • Rui et al. identify Janus kinase 2 (JAK2) and Jumonji domain-containing protein 2C (JMJD2C) as coamplified oncogenes in primary mediastinal B-cell lymphoma and Hodgkin lymphoma.
  • These two genes are located contiguously on chromosome 9p24.1, a region frequently amplified in these malignancies.
  • The coamplification of JAK2 and JMJD2C leads to significant alterations in chromatin structure and gene expression, driving oncogenesis.

Key Insights:

  • JAK2 and JMJD2C are identified as key oncogenes in primary mediastinal B-cell lymphoma and Hodgkin lymphoma.
  • Coamplification of these genes induces substantial changes in chromatin organization and gene expression profiles.
  • This discovery highlights a novel genetic vulnerability in these B-cell lymphomas.

Outlook:

  • Targeting JAK2 and JMJD2C with small molecule inhibitors presents a promising new therapeutic avenue.
  • Further research into the precise mechanisms of JAK2 and JMJD2C cooperation may reveal additional therapeutic targets.
  • Developing targeted therapies could improve outcomes for patients with these challenging lymphomas.

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