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Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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Updated: Jun 6, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Neuropsychological functioning in PLS: a comparison with ALS.

Gloria M Grace1, J B Orange, Ann Rowe

  • 1Clinical Neurological Sciences and Psychological Services, London Health Sciences Centre, Ontario.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|December 16, 2010
PubMed
Summary
This summary is machine-generated.

Primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) patients show similar cognitive and behavioral deficits, particularly in executive functions. Many patients exhibit impairments, highlighting the need for neuropsychological assessment.

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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
07:00

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Psychology

Background:

  • Primary Lateral Sclerosis (PLS) is a rare motor neuron disease.
  • Neuropsychological dysfunction is recognized in Amyotrophic Lateral Sclerosis (ALS).
  • The cognitive, emotional, and behavioral profile of PLS requires further characterization.

Purpose of the Study:

  • To characterize neuropsychological dysfunction in PLS.
  • To compare cognitive, emotional, and behavioral functioning in PLS versus ALS.
  • To identify specific cognitive domains affected in these conditions.

Main Methods:

  • A prospective study involving 18 PLS patients and 13 ALS patients.
  • Administration of a comprehensive neuropsychological test battery.
  • Assessment of cognitive skills, emotional, and behavioral functioning.

Main Results:

  • Both PLS and ALS groups generally scored within normal cognitive limits.
  • Significant heterogeneity was observed; 39% of PLS and 31% of ALS patients were cognitively impaired.
  • Executive function tests revealed frequent abnormalities in both groups; a majority of PLS patients also had behavioral symptoms.

Conclusions:

  • A substantial proportion of PLS patients exhibit cognitive and behavioral deficits comparable to ALS.
  • Deficits were most prominent in executive functioning for both PLS and ALS.
  • Findings suggest overlapping neuropsychological profiles between PLS and ALS, distinct from frontotemporal dementia.