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Updated: Jun 6, 2026
Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images
Published on: May 19, 2023
Comparison of robot-assisted and manual retinal vessel microcannulation in an animal model
Takashi Ueta1, Taiga Nakano, Yoshiki Ida
1Department of Ophthalmology, School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. ueta-tky@umin.ac.jp
Aim:
To evaluate the performance of a parallel robotic system by comparison with the conventional manual procedure using an animal model.
Methods:
A new parallel robotic system was developed that features a small cylindrical manipulator (base diameter 76 mm, height 240 mm). The performance of the new system was evaluated for its capability to assist in retinal vessel microcannulation. The test scenario was as follows: (1) introduce the microcannula into a harvested porcine eye attached loosely on the orbital fossa of an artificial face model through a 20G scleral port at the pars plana; (2) cannulate the retinal vessels (inner diameter 60-80 μm); and (3) inject indocyanine green dye into the eye endovascularly. The success rate and procedure quality of the robotic system were evaluated by comparison with the conventional manual procedure.
Results:
Retinal vessel microcannulation and dye injection were achieved by the robotic system twice in four attempts, and by the conventional manual procedure either not at all or incompletely in all six attempts. Dye leakage was not observed with the robotic system, indicating that microcannulation was minimally invasive; in contrast, dye leakage was always observed with the manual procedure.
Conclusions:
The new system is more accurate than the conventional manual procedure for the tests on a porcine eye model.
