Related Experiment Video
Updated: Jun 6, 2026

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds
Published on: April 6, 2016
Growth curve analysis of tumourigenesis using cellular level cancer model
1Radiation Effect Analysis Group, Division of Environment and Radiation Sciences, Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency, Tokai, Ibaraki 319-1195, Japan. ouchi.noriyuki@jaea.go.jp
Abstract:
It is known that carcinogenesis by low-dose radiation will start from DNA damage by ionising radiation. After the long time period, these very small effects will appear on a cellular scale by accumulation of various intracellular biological responses and finally grow to the tumour with clonal expansion of cancer cell. Thus, the biological radiation effects are phenomena with a very wide scale from DNA damage (10(-9) m, 10(-6) s) to the tumour (10(-3) m, 10(5) s); so the risk estimation of low-dose radiation is difficult to study by the experiments. To overcome these difficult situations at low-dose radiation effects' problems, it is good to study the process of carcinogenesis using a biologically based mathematical model. This study's cellular-scale mathematical model of tumourigenesis and some results of the statistical calculations about the tumour growth as presented in the work.
Related Concept Videos
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
What is Cancer?
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer Survival Analysis
Cancer
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

