Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Y-to-Y Circuit01:19

The Y-to-Y Circuit

In a balanced four-wire wye-to-wye system, the arrangement involves wye-connected sinusoidal voltage sources and loads, connected through a neutral wire that links the neutral nodes of the source and load. The load impedance is connected across each phase of the load. The wye-connected source can be connected to the wye-connected load in four-wire and three-wire arrangements. A three-phase system is considered balanced when the load on each phase is equal, leading to uniform current flow and...
Rules for Defining Functions01:29

Rules for Defining Functions

A relation is a function if each input x is associated with exactly one output y. For example, the equation      y = 2x + 5 defines a function because every value of x yields a unique y. However, x = y² + 1 is not a function of x, since a single x-value, such as x = 2, corresponds to two possible y-values: y = 1 and y = -1.The vertical line test helps determine whether a graph represents a function. If a vertical line intersects a curve more than once, the curve fails the test and does not...
Fates of Pyruvate01:20

Fates of Pyruvate

Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Acidity of 1-Alkynes02:42

Acidity of 1-Alkynes


The acidic strength of hydrocarbons follows the order: Alkynes > Alkenes > Alkanes. The strength of an acid is commonly expressed in units of pKa — the lower the pKa, the stronger the acid. Among the hydrocarbons, terminal alkynes have lower pKa values and are, therefore, more acidic. For example, the pKa values for ethane, ethene, and acetylene are 51, 44, and 25, respectively, as shown here.
Flail Chest-II01:26

Flail Chest-II

Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
Assessment:
1. Clinical Evaluation:
History:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oncogenic PIK3CA reprograms glutamine metabolism to drive bladder cancer progression.

Cell communication and signaling : CCS·2026
Same author

Conditional Knockout of Indoleamine 2, 3-Dioxygenase-1 in Osteoprogenitor Cells in Mice Results in Sex-dependent Differences in Bone Mass.

Biochimie·2026
Same author

The association of hidradenitis suppurativa with increased risk of systemic infections in end-stage renal disease.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026
Same author

Crosstalk with bone marrow adipocytes, but not osteoblasts, drives a cortical bone resorption phenotype in female mice with adult-onset deletion of the glucocorticoid receptor in Osterix-expressing cells.

JBMR plus·2026
Same author

Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression.

Cancer letters·2026
Same author

Nail changes associated with mortality in end-stage renal disease: A national retrospective cohort study.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2026

Related Experiment Video

Updated: Jun 6, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
09:58

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts

Published on: February 24, 2015

Wherefore art thou, YY1?

Wendy B Bollag1, Roni J Bollag

  • 1Charlie Norwood VA Medical Center, Augusta, Georgia, USA. wbollag@mcg.edu

The Journal of Investigative Dermatology
|December 16, 2010
PubMed
Summary

The transcription factor Yin Yang-1 (YY1) promotes skin cell proliferation and epidermal thickening. YY1 also inhibits keratinocyte differentiation, highlighting its role in skin structure and function.

Area of Science:

  • Cell Biology
  • Dermatology
  • Molecular Biology

Background:

  • The transcription factor Yin Yang-1 (YY1) is a known regulator of various cellular processes.
  • Understanding YY1's role in keratinocyte biology is crucial for skin development and disease.

Discussion:

  • This study investigates the function of YY1 in three-dimensional HaCaT human keratinocyte cultures.
  • Results indicate that YY1 overexpression leads to thicker artificial epidermal constructs.
  • YY1 knockdown reverses this thickening, confirming its role in proliferation and epidermal morphogenesis.

Key Insights:

  • Yin Yang-1 (YY1) directly regulates keratinocyte proliferation and epidermal stratification.
  • Overexpression of YY1 enhances the formation of thicker epidermal constructs in vitro.

More Related Videos

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
11:25

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

Published on: February 11, 2019

Visualizing Uniaxial-strain Manipulation of Antiferromagnetic Domains in Fe1+YTe Using a Spin-polarized Scanning Tunneling Microscope
09:06

Visualizing Uniaxial-strain Manipulation of Antiferromagnetic Domains in Fe1+YTe Using a Spin-polarized Scanning Tunneling Microscope

Published on: March 24, 2019

Related Experiment Videos

Last Updated: Jun 6, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
09:58

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts

Published on: February 24, 2015

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
11:25

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

Published on: February 11, 2019

Visualizing Uniaxial-strain Manipulation of Antiferromagnetic Domains in Fe1+YTe Using a Spin-polarized Scanning Tunneling Microscope
09:06

Visualizing Uniaxial-strain Manipulation of Antiferromagnetic Domains in Fe1+YTe Using a Spin-polarized Scanning Tunneling Microscope

Published on: March 24, 2019

  • YY1 activity is essential for maintaining epidermal structure and inhibiting differentiation.

    • Outlook:

    • Further research into YY1's precise molecular mechanisms in keratinocytes could reveal therapeutic targets.
    • Investigating YY1's role in skin diseases characterized by altered proliferation or differentiation is warranted.