Hyalinizing trabecular tumor of the thyroid gland

Area of Science:

• Endocrinology
• Surgical Pathology
• Cytopathology

Background:

• Hyalinizing trabecular tumor (HTT) is a rare and controversial thyroid neoplasm.
• Its classification remains debated, with considerations as a unique entity, a variant of papillary carcinoma, or a nonspecific pattern.
• While histological and ultrastructural features are documented, cytological diagnosis via fine needle aspiration cytology (FNAC) is challenging due to overlapping features.

Observation:

• This report details a case of HTT in a 28-year-old male.
• The fine needle aspiration cytology (FNAC) findings are presented.
• Cytomorphological features that mimic both papillary and medullary thyroid carcinomas are discussed.

Findings:

• The cytomorphological characteristics of HTT were evaluated.
• Differential diagnostic considerations for HTT on FNAC are explored.
• The case illustrates the diagnostic challenges posed by HTT.

Implications:

• Accurate cytological diagnosis of HTT is crucial for appropriate patient management.
• Understanding the cytomorphological spectrum of HTT can improve diagnostic accuracy.
• This case contributes to the literature on the cytopathology of rare thyroid lesions.