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Managing hyponatremia in cirrhosis
Elizabeth Ross1, Samuel H Sigal
1Division of Gastroenterology, Department of Medicine, New York University School of Medicine, New York, New York.
Abstract:
The development of hyponatremia represents an ominous event in the progression of cirrhosis to end-stage liver disease. It usually develops in those with refractory ascites and is a manifestation of the non-osmotic release of arginine vasopressin (AVP). In the hospitalized cirrhotic patient, hyponatremia is associated with increased disease severity and mortality. In this article, we review the pathophysiology of hyponatremia, its clinical implications, evaluation, and treatment.
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