[Induction of glucocorticoid hormone receptors in continuous human T-lymphocyte cultures (proceedings)]

The presence is documented of high levels of specific glucocorticoid hormone receptors in human cultured T cells (CTC) maintained with a conditioned medium. When conditioned medium was removed from CTC for 24 h, receptor levels reverted to those of fresh, unstimulated lymphocytes. When conditioned medium, or phytohemagglutinin, was then added at various times before testing for glucocorticoid receptors, these stimuli were shown gradually to induce more receptor activity, beginning at about 10 h of stimulation and increasing to 10-fold through 24 h.