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Grossing of Non-neoplastic Globes, Including Fetal Eyes

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Congenital cystic eye: a clinicopathologic study.

Mridula Mehta¹, Neelam Pushker, Seema Sen

¹Paediatric Ophthalmology and Ophthalmoplasty Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Journal of Pediatric Ophthalmology and Strabismus

|December 17, 2010

Summary

Congenital cystic eye, a rare ocular anomaly, involves eyeball replacement by cystic or neuroglial tissue due to optic vesicle malformation. This case highlights its association with ectopic brain glial tissue, a rare co-occurrence.

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Area of Science:

Ophthalmology
Developmental Biology
Neuroscience

Background:

Congenital cystic eye is an extremely rare congenital ocular anomaly.
It results from the failure of optic vesicle invagination, leading to eyeball replacement by cystic or neuroglial tissue.

Observation:

This study presents a case of a 13-year-old girl with congenital cystic eye.
Clinical, imaging, intraoperative, and histopathological findings are detailed.
A rare association with ectopic glial tissue in the brain was noted.

Findings:

The case confirmed the typical pathological features of congenital cystic eye.
Histopathology revealed neuroglial tissue replacing the normal ocular structures.
The co-occurrence of ectopic glial tissue in the brain was confirmed.

Implications:

This case expands the understanding of congenital cystic eye and its rare associations.
It underscores the importance of comprehensive evaluation for associated central nervous system anomalies.
Further research into the developmental mechanisms underlying this anomaly and its brain associations is warranted.