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Related Experiment Video

Updated: Jun 6, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
03:47

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

Laser systems for ablative fractional resurfacing.

Uwe Paasch1, Merete Haedersdal

  • 1University of Leipzig, Department for Dermatology, Venerology and Allergology, Philipp-Rosenthal-Strasse 23, 04103 Leipzig, Germany. Uwe.Paasch@medizin.uni-leipzig.de

Expert Review of Medical Devices
|December 17, 2010
PubMed
Summary
This summary is machine-generated.

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Ablative fractional resurfacing (AFR) uses lasers to create microscopic channels in the skin, promoting remodeling for treating skin conditions and drug delivery. Further research is needed to optimize system settings for clinical outcomes.

Area of Science:

  • Dermatology
  • Laser Technology
  • Aesthetic Medicine

Background:

  • Ablative fractional resurfacing (AFR) creates microscopic treatment zones (MTZs) by generating vertical channels with surrounding coagulated tissue.
  • AFR stimulates epidermal and dermal remodeling, offering potential for treating photodamaged skin, acne scars, and burn scars.
  • The technology also shows promise for laser-assisted topical drug delivery.

Purpose of the Study:

  • To provide an overview of ablative fractional resurfacing (AFR) technology, devices, and histopathology.
  • To summarize current clinical applications of AFR, including personal experiences.
  • To highlight the need for systematic investigations into clinical outcomes based on varying system settings.

Main Methods:

  • Review of ablative fractional resurfacing (AFR) technology and available laser systems (CO2, Er:YAG, YSGG).

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Last Updated: Jun 6, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
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  • Discussion of histopathological changes induced by AFR.
  • Summary of clinical applications and personal experiences with AFR.

    • Main Results:

    • AFR induces microscopic vertical ablated channels and surrounding coagulated tissue (MTZs).
    • AFR promotes epidermal and dermal remodeling, beneficial for various skin conditions.
    • Multiple fractional ablative laser systems are available, including CO2, Er:YAG, and YSGG lasers.

    Conclusions:

    • AFR is a promising technology for skin rejuvenation and scar treatment with minimal downtime.
    • Potential applications include treating photodamaged skin, acne, and burn scars, as well as enhancing topical drug delivery.
    • AFR is in an exploratory phase, requiring further systematic research to optimize clinical outcomes and device settings.