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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...

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Related Experiment Video

Updated: Jun 6, 2026

Examination of Oral Candida Infection in Primary Sj&#246;gren&#39;s Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Ocular fungal infections.

Ayse Kalkanci1, Sengul Ozdek

  • 1Medical Microbiology Department, Faculty of Medicine, Gazi University, Ankara, Turkey. aysekalkanci@email.com

Current Eye Research
|December 17, 2010
PubMed
Summary

Ocular fungal infections, particularly in developing nations, cause significant vision loss. This review highlights laboratory diagnosis, experimental models, and therapeutic strategies for ophthalmic mycoses to improve patient outcomes.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Ocular fungal infections are a major cause of visual impairment, especially in developing countries.
  • Trauma is a significant risk factor, with Fusarium, Aspergillus, and Candida being common pathogens.

Purpose of the Study:

  • To provide an overview of ocular fungal infections from a clinical and microbiological perspective.
  • To review laboratory diagnostic methods and experimental models for ophthalmic mycoses.

Main Methods:

  • A comprehensive review of published literature on ocular mycoses.
  • Inclusion of personal experience and clinical observations.

Main Results:

  • Fungal infections are categorized by the affected ocular structure.

Related Experiment Videos

Last Updated: Jun 6, 2026

Examination of Oral Candida Infection in Primary Sj&#246;gren&#39;s Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

  • Culture remains the gold standard for diagnosis, while microscopy offers rapid presumptive identification.
  • Serological and molecular techniques are increasingly utilized, alongside evaluated antifungal therapies.
  • Experimental models are crucial for advancing research into pathophysiology, immunology, and treatment.

    • Conclusions:

    • Ocular fungal infections represent a significant global health challenge, impacting vision and quality of life.
    • Enhanced understanding of these infections is vital for improving clinical management and patient prognosis.