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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
Advances in nano drugs for cancer chemotherapy
Imran Ali1, Rahis-Uddin, K Salim
1Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi - 110025, India. drimran_ali@yahoo.com
Abstract:
In spite of some medications, millions of peoples are dying every year due to cancer. Additionally, the survival patients suffer from various serious side effects due to the use of available anti-neoplastic medicines. The development of nanoparticles based drugs is seems to be effective providing low side effects and targeted action on cancer cells. The present article describes the state-of-art of nano drugs in cancer chemotherapy. The nano drugs are targeted selective and specific towards tumors only resulting into better treatment. The important molecules used for preparation nano drugs are cisplatin, carboplatin, bleomycin, 5-fluorouracil, doxorubicin, dactinomycin, 6-mercaptopurine, paclitaxel, topotecan, vinblastin and etoposide etc. The most commonly used materials for preparing nanoparticles carriers are dendrimers, polymer, liposome, micelles, inorganic, organic nanoparticles etc. A survey was carried out on the drugs available in the market and given in tabular form. However, the commonly used nano drugs till date are liposome dendrimer and some other materials based nanoparticles. Attempts have been made to explain mechanism of action of nano drugs. The future perspectives have also been highlighted in to the conclusion part.
Insights
Nanoparticle-based chemotherapy offers a promising approach to cancer treatment, minimizing side effects and targeting tumors effectively. This review explores the current state of nano drugs in cancer therapy.
Area of Science:
- Oncology
- Nanotechnology
- Drug Delivery
Background:
- Cancer remains a leading cause of mortality worldwide.
- Current anti-neoplastic drugs often cause severe side effects in survivors.
- Nanoparticle-based drug delivery systems offer a potential solution for targeted cancer therapy.
Purpose of the Study:
- To review the current advancements in nanoparticle-based drugs for cancer chemotherapy.
- To highlight the advantages of nano drugs, including targeted action and reduced side effects.
- To discuss the materials and molecules used in the development of nano drugs.
Main Methods:
- Review of existing literature on nano drugs in cancer chemotherapy.
- Survey of commercially available nano drugs.
- Explanation of the mechanisms of action for nano drugs.
Main Results:
- Nanoparticle-based drugs demonstrate targeted selectivity towards tumors, improving treatment efficacy.
- Commonly used molecules include cisplatin, paclitaxel, and doxorubicin.
- Materials like liposomes, dendrimers, and polymers are frequently employed as nanoparticle carriers.
Conclusions:
- Nanodrugs represent a significant advancement in cancer chemotherapy, offering improved efficacy and safety profiles.
- Future research should focus on further optimizing nanodrug formulations and understanding their long-term effects.
- Continued development in nanomedicine holds great promise for revolutionizing cancer treatment.
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