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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

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[Hyperhomocysteinemia among ischemic stroke victims in the teaching hospital of Lomé]

Kombate Damelan1, Assogba Kom, Apetse Kossivi

  • 1Service de neurologie, CHU Campus de Lomé, Togo. damelan03@yahoo.fr

Annales De Biologie Clinique
|December 17, 2010
PubMed

Insights

Hyperhomocysteinemia, elevated homocysteine levels, is prevalent in 61% of ischemic stroke patients. This metabolic factor is a significant vascular risk, second only to hypertension, potentially linked to nutritional causes.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Biochemistry

Context:

  • Ischemic stroke is a leading cause of disability and mortality.
  • Hyperhomocysteinemia is a recognized independent risk factor for vascular diseases.
  • Understanding the prevalence and determinants of hyperhomocysteinemia in stroke patients is crucial for targeted interventions.

Purpose:

  • To determine the prevalence of hyperhomocysteinemia in patients diagnosed with ischemic stroke.
  • To investigate the role of metabolic determinants, including age and stroke subtype, in hyperhomocysteinemia.
  • To identify hyperhomocysteinemia as a vascular risk factor in the studied population.

Summary:

  • A study of 183 ischemic stroke patients in Lome revealed a 61% prevalence of hyperhomocysteinemia.
  • Average homocysteine levels were higher in men and correlated positively with age in both sexes.
  • Elevated homocysteine levels were significantly associated with stroke severity, particularly when lacunes and leucoaraiosis were present.

Impact:

  • This research highlights hyperhomocysteinemia as a significant, potentially nutrition-related, vascular risk factor in ischemic stroke patients.
  • Findings suggest the need for routine homocysteine level screening in stroke patients for risk stratification and management.
  • The study provides valuable epidemiological data on hyperhomocysteinemia in a West African population, informing public health strategies.

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