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Updated: Jun 6, 2026

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
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Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure

Published on: February 12, 2018

Intralipid: towards a diffusive reference standard for optical tissue phantoms.

Paola Di Ninni1, Fabrizio Martelli, Giovanni Zaccanti

  • 1Dipartimento di Fisica e Astronomia dell'Università degli Studi di Firenze, Via G. Sansone 1, 50019 Sesto Fiorentino, Firenze, Italy.

Physics in Medicine and Biology
|December 17, 2010
PubMed
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Intralipid 20% exhibits high optical property stability across multiple batches and years. This suggests its potential as a reliable standard for tissue-simulating phantoms in research.

Area of Science:

  • Biomedical Optics
  • Materials Science

Background:

  • Intralipid 20% is widely used in biomedical optics for tissue phantoms.
  • Variability in optical properties can affect phantom accuracy.
  • A stable, reproducible phantom material is needed for reliable research.

Purpose of the Study:

  • To assess the optical property stability of Intralipid 20%.
  • To determine batch-to-batch variations in Intralipid 20%.
  • To evaluate Intralipid 20% as a potential reference standard for tissue phantoms.

Main Methods:

  • Optical properties (absorption and scattering coefficients) were measured.
  • Measurements were performed at visible and near-infrared (NIR) wavelengths.
  • Samples from nine different batches spanning ten years were analyzed.

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Last Updated: Jun 6, 2026

Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
10:22

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Published on: February 12, 2018

Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
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Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

Published on: August 22, 2018

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Main Results:

  • High stability and low batch-to-batch variations in optical properties were observed.
  • Reduced scattering coefficients averaged 25.9, 21.2, and 18.4 mm⁻¹ at 632.8, 751, and 833 nm, respectively.
  • Absorption coefficients were comparable to or slightly different from pure water.

Conclusions:

  • Intralipid 20% demonstrates remarkable consistency in its optical properties.
  • These findings support Intralipid 20% as a promising candidate for a diffusive reference standard.
  • It can advance the development of accurate tissue-simulating phantoms.