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Beta-fibrinogen G-455A polymorphisms and recurrent miscarriage.

Carlo Ticconi¹, Francesca Mancinelli, Paolo Gravina

¹Department of Surgery, Section of Gynecology and Obstetrics, Tor Vergata University, Rome, Italy. ticconi@med.uniroma2.it

Gynecologic and Obstetric Investigation

|December 17, 2010

Summary

The β-fibrinogen G-455A A/A genotype may increase the risk of recurrent miscarriage (RM). However, allele frequencies did not differ between women with RM and controls, suggesting a minimal effect of this polymorphism on RM.

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Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

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Published on: August 4, 2021

Area of Science:

Genetics
Reproductive Medicine
Hematology

Background:

Recurrent miscarriage (RM) is a complex condition affecting reproductive health.
The role of genetic factors, specifically β-fibrinogen G-455A polymorphism, in RM is under investigation.

Purpose of the Study:

To determine if genotype and allele frequencies of β-fibrinogen G-455A differ in women experiencing recurrent miscarriage (RM).

Main Methods:

Sequencing analysis was employed to investigate the β-fibrinogen G-455A polymorphism.
The study included 98 women with RM and 78 control women without a history of miscarriage.

Main Results:

A significant difference in the β-fibrinogen G-455A A/A genotype frequency was observed between women with RM and controls.
The A/A genotype was present in 8.2% of women with RM but was absent in the control group.
No significant differences were found in the allele frequencies of β-fibrinogen G-455A between the RM and control groups.

Conclusions:

The A/A genotype of β-fibrinogen G-455A may be associated with an increased risk of recurrent miscarriage.
The similar allele frequencies suggest that the impact of this specific β-fibrinogen polymorphism on RM is likely very slight.