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Updated: Jun 6, 2026
17:13
Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
Urinary biomarkers in acute kidney transplant dysfunction.
Nada Alachkar1, Hamid Rabb, Bernard G Jaar
1Division of Nephrology, Department of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA. nalachk1@jhmi.edu
Nephron. Clinical Practice
|December 17, 2010
Summary
New biomarkers offer a promising alternative to kidney transplant biopsies for diagnosing acute kidney injury. These advancements in acute allograft dysfunction research could improve patient and graft survival.
Area of Science:
- Nephrology
- Transplantation immunology
- Biomarker discovery
Background:
- Acute kidney injury (AKI) is a frequent complication in kidney transplant recipients, impacting patient and allograft survival.
- Kidney allograft biopsy is the current standard for diagnosing impaired function but carries risks like bleeding and sampling errors.
Purpose of the Study:
- To review the literature on key biomarkers for acute allograft dysfunction.
- To assess the clinical significance of these biomarkers in kidney transplantation.
Main Methods:
- Comprehensive literature review.
- Analysis of published data on relevant biomarkers and their clinical significance.
Main Results:
- Several significant biomarkers have been identified.
- These biomarkers correlate with biopsy findings, clinical outcomes, and potentially graft survival.
Conclusions:
- The identification of surrogate biomarkers is a critical and evolving area in kidney transplantation.
- Further collaborative research is essential to advance this field.
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