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Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Cancers Originate from Somatic Mutations in a Single Cell

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Related Experiment Video

Updated: Jun 6, 2026

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

[Cancer stem cells in solid tumors].

Hajime Hirose¹, Hirofumi Yamamoto, Norikatsu Miyoshi

¹Dept. of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|December 17, 2010

Summary

Cancer stem cells (CSCs) in solid tumors self-renew and differentiate, driving cancer progression and treatment resistance. Identifying CSCs is crucial for developing targeted cancer therapies.

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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

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Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

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Published on: May 11, 2016

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

Oncology
Cell Biology
Cancer Research

Context:

Cancer stem cells (CSCs) are a subpopulation of cells within tumors responsible for tumor initiation, growth, and metastasis.
While CSCs have been known in leukemia for decades, recent advancements in cell surface marker identification have enabled their discovery in various solid tumors.
These tumors include breast, prostate, lung, brain, colon, and pancreatic cancers.

Purpose:

To review current understanding and recent developments concerning cancer stem cells, with a specific focus on their role in solid tumors.
To highlight the characteristics of CSCs, including self-renewal, multi-potential differentiation, and tumorigenic potential.
To discuss the implications of CSCs in cancer progression, recurrence, metastasis, and resistance to conventional therapies like chemotherapy and radiotherapy.

Summary:

Cancer stem cells possess unique properties such as self-renewal, multi-potential differentiation, and the ability to initiate tumors.
CSCs exhibit significant resistance to anticancer drugs and radiotherapy, contributing to treatment failure.
Recent identification techniques using cell surface markers have confirmed the presence of CSCs in numerous solid tumors, expanding beyond leukemia.

Impact:

The identification and understanding of CSCs are pivotal for advancing cancer treatment strategies.
Targeting cancer stem cells holds promise as a future therapeutic approach to overcome treatment resistance and prevent cancer recurrence and metastasis.
Further research into CSC biology is expected to yield novel and more effective cancer therapies.