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Proton therapy dosimetry using positron emission tomography.

Matthew T Studenski¹, Ying Xiao

¹Matthew T Studenski, Ying Xiao, Bodine Cancer Center, Department of Radiation Oncology, Thomas Jefferson University Hospital, 111 S. 11th St., Room G-321 Gibbon Building, Philadelphia, PA 19107, United States.

World Journal of Radiology

|December 17, 2010

Summary

Proton therapy precisely targets tumors, sparing healthy tissue. Positron emission tomography (PET) systems are being reviewed for in vivo dosimetry to accurately monitor proton beam dose deposition during treatment.

Keywords:

Dosimetry Positron emission tomography Proton therapy

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Area of Science:

Medical Physics
Radiotherapy
Nuclear Medicine

Background:

Proton therapy offers precise dose deposition at the end of its path, sparing surrounding healthy tissues.
Accurate dosimetry is crucial in proton therapy to ensure the tumor, not healthy tissue, receives the radiation dose.
In vivo dosimetry methods are needed for real-time monitoring during clinical treatments.

Purpose of the Study:

To review current research on in vivo dosimetry methods for proton therapy.
To summarize the advantages and limitations of online and offline monitoring using positron emission tomography (PET).
To assess the feasibility of PET-based dosimetry for accurate dose deposition monitoring.

Main Methods:

Review of current scientific literature on in vivo dosimetry in proton therapy.
Analysis of online (in-beam) and offline monitoring techniques utilizing positron emission tomography (PET).
Investigation of the underlying physics of PET-based dosimetry, involving proton-induced nuclear reactions and positron emitter production.

Main Results:

PET-based dosimetry, both online and offline, shows promising results for monitoring proton beam paths.
These methods allow for the determination of positron emitter locations, correlating with proton dose deposition.
Coupling PET imaging with patient anatomy aids in monitoring tumor location and dose distribution.

Conclusions:

PET imaging is a valuable tool for in vivo dosimetry in proton therapy.
Both online and offline PET monitoring methods have demonstrated potential for accurate dose deposition verification.
Further research is needed to optimize these techniques and address their limitations for widespread clinical adoption.