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Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 6, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Malignant peritoneal mesothelioma.

Stine Munkholm-Larsen1, Christopher Q Cao, Tristan D Yan

  • 1Stine Munkholm-Larsen, Christopher Q Cao, Tristan D Yan, University of Sydney, Department of Cardiothoracic Surgery, Royal Prince Alfred Hospital, Sydney 2050, Australia.

World Journal of Gastrointestinal Surgery
|December 17, 2010
PubMed
Summary
This summary is machine-generated.

Diffuse malignant peritoneal mesothelioma (DMPM) survival has significantly improved with combined surgery and chemotherapy. This review highlights recent advances in DMPM epidemiology, diagnosis, staging, treatment, and prognosis.

Keywords:
AsbestosCisplatinCytoreductive surgeryDoxorubicinIntraperitoneal chemotherapyMesothelinPemetrexedPeritoneal mesotheliomaPeritonectomy

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Published on: October 2, 2015

Area of Science:

  • Oncology
  • Medical Science

Background:

  • Malignant mesothelioma is an aggressive cancer with increasing incidence globally.
  • Diffuse malignant peritoneal mesothelioma (DMPM) accounts for 25% of mesotheliomas, often linked to asbestos exposure.
  • Historically considered terminal, DMPM outcomes have changed due to modern treatments.

Purpose of the Study:

  • To review key advances in DMPM over the last decade.
  • To focus on epidemiology, diagnosis, staging, treatments, and prognosis.
  • To provide an updated perspective on this previously overlooked disease.

Main Methods:

  • Review of recent prospective trials and medical literature.
  • Analysis of epidemiological data and diagnostic advancements.
  • Evaluation of current treatment strategies and prognostic factors.

Main Results:

  • Combined cytoreductive surgery and perioperative intraperitoneal chemotherapy significantly improve survival.
  • Median survival ranges from 40-90 months; 5-year survival rates are 30-60%.
  • Recent research has revitalized interest in DMPM due to improved outcomes.

Conclusions:

  • DMPM is no longer considered a pre-terminal condition.
  • Advances in multimodal therapy have dramatically improved patient prognosis.
  • Further research into DMPM is warranted given its improved survival rates.