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Updated: May 17, 2026

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
Published on: March 24, 2023
Natural orifice surgery applied for colorectal diseases
1Ricardo Zorron, Department of Surgery, University Hospital Teresopolis HCTCO-FESO, Rio de Janeiro 22790-700, Brazil; Department of Surgery, Hospital Municipal Lourenço Jorge, Rio de Janeiro 22790-700, Brazil.
Transcolonic natural orifice transluminal endoscopic surgery (NOTES) offers a new minimally invasive approach for colorectal diseases. First human applications show promise for treating rectal cancer and benign conditions, improving patient care.
Area of Science:
- Minimally Invasive Surgery
- Gastroenterology
- Colorectal Surgery
Background:
- Clinical natural orifice surgery, primarily transvaginal and transgastric, is established in abdominal procedures.
- Transcolonic natural orifice transluminal endoscopic surgery (NOTES) has shown potential for colorectal diseases but lacked clinical application.
- Previous research focused on animal and cadaver models for transcolonic NOTES.
Purpose of the Study:
- To report the first successful human applications of transcolonic NOTES.
- To explore new transrectal procedures for rectal cancer and benign diseases using NOTES.
- To evaluate the potential of flexible Perirectal NOTES Access for colorectal disease treatment.
Main Methods:
- First human applications of transcolonic NOTES were performed by the NOTES Research Group in Brazil.
- Procedures involved transrectal access for colorectal disease treatment.
- Evaluation of clinical outcomes for transrectal NOTES procedures.
Main Results:
- Successful first human applications of transcolonic NOTES were documented.
- New transrectal procedures for rectal cancer and benign conditions were demonstrated.
- This approach offers a promising alternative to traditional surgery.
Conclusions:
- Transcolonic NOTES represents a significant advancement in minimally invasive colorectal surgery.
- The successful human application opens new frontiers for NOTES in treating colorectal diseases.
- Flexible Perirectal NOTES Access enhances patient care options for colorectal conditions.
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