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Updated: Jun 6, 2026
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Published on: May 17, 2013
Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan
Mei-Due Yang1, Ru-Yin Tsai, Chiu-Shong Liu
1Mei-Due Yang, Chao-Hsiang Chang, Hwei-Chung Wang, Department of Surgery, China Medical University Hospital, 2 Yuh-Der Road, Taichung 404, Taiwan, China.
Aim:
To investigate the association of Caveolin-1 (Cav-1) polymorphisms with colorectal cancer (CRC) risk in a central Taiwanese population.
Methods:
Three hundred and sixty-two patients with colorectal cancer and the same number of recruited age- and gender-matched healthy controls were genotyped. And only those matches with all single nucleotide polymorphisms data (case/control = 362/362) were selected for final analyzing.
Results:
There were significant differences between CRC and control groups in the distributions of their genotypes (P = 1.6 × 10(-12) and 3.0 × 10(-4)) and allelic frequencies (P = 2.3 × 10(-13) and 4.0 × 10(-5)) in the Cav-1 G14713A (rs3807987) and T29107A (rs7804372) polymorphisms respectively. As for the haplotype analysis, those who had GG/AT or GG/AA at Cav-1 G14713A/T29107A showed a 0.68-fold (95% CI: 0.48-0.98) decreased risk of CRC compared to those with GG/TT, while those of any other combinations were of increased risk. There were joint effects of Cav-1 G14713A and T29107A genotype with smoking status on individual CRC susceptibility.
Conclusion:
This is the first report providing evidence of Cav-1 being involved in CRC and it may be novel useful genomic markers for early detection of CRC.
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