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Updated: Jan 3, 2026

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
Three novel NEIL1 promoter polymorphisms in gastric cancer patients
Masanori Goto1, Kazuya Shinmura, Hong Tao
1Masanori Goto, Kazuya Shinmura, Hong Tao, Haruhiko Sugimura, First Department of Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, Shizuoka 431-3192, Japan.
Aim:
To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients.
Methods:
The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses.
Results:
Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients.
Conclusion:
Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.
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