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Updated: Jun 6, 2026
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
Published on: February 17, 2023
[Doxycycline nano-liposome slow-release gel improves rat periodontitis]
Hong-lai Jin1, Wei Wu, Rong Shu
1Department of Stomatology, Zhoupu Hospital, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201318, China. jinhonglai@sohu.com
Purpose:
To evaluate the therapeutic effects of doxycycline nano-liposome slow-release gel on the periodontitis in an established rat model.
Methods:
The biocompatibility was tested by oral perfusion sample gel for long term observation. Doxycycline nano-gel was used to treat the established rat model of periodontitis. The rats were selected randomly and divided into five groups: blank group, doxycycline nano-gel treated group, minocycline-treated group, matrix group and periodontitis model group. MMP-8 and TIMP-1 in the sulcus fluid were detected by real-time PCR. The data was analysed using SAS13.3 software package for Student's t test.
Results:
Doxycycline nano-gel had excellent biocompatibility from weight measure and tissue section evaluation. The results in periodontitis rats demonstrated that doxycycline nano-gel could ameliorate periodontitis condition dramatically compared with the control group, the restoration even better than minocycline-treated group.
Conclusions:
Doxycycline nano-liposome slow-release gel improves rat periodontitis by decreasing MMP-8 level, which provides valuable evidence to promote doxycycline nano-gel clinical application.
