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Current evidence on the relationship between four polymorphisms in the matrix metalloproteinases (MMP) gene and

Ping Zhou1, Liang-Feng Du, Guo-Qiang Lv

  • 1Department of Intensive Care Unite, The Third Affiliated Hospital to Nantong University, Wuxi 214041, Jiangsu, China.

Breast Cancer Research and Treatment
|December 17, 2010
PubMed

Insights

Genetic variations in matrix metalloproteinases (MMP) and breast cancer risk were examined. A meta-analysis found the MMP-2 -1306 C/T polymorphism is associated with increased breast cancer susceptibility.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Matrix metalloproteinases (MMPs) degrade extracellular matrix components.
  • Functional genetic polymorphisms in MMPs may influence breast cancer risk.
  • Previous studies on MMP polymorphisms and breast cancer risk have yielded controversial results.

Purpose of the Study:

  • To investigate the association between four specific MMP gene polymorphisms and breast cancer risk.
  • To clarify the controversial relationship between MMPs and breast cancer susceptibility.

Main Methods:

  • A meta-analysis was performed on 9 studies with 2,597 cases and 2,618 controls.
  • Four polymorphisms were analyzed: MMP-1 -1607 2G/1G (rs1799750), MMP-2 -1306 C/T (rs243865), MMP-3 -1171 6A/5A (rs3025058), and MMP-9 -1562 C/T (rs3918242).
  • Crude odds ratios (OR) with 95% confidence intervals (CI) were calculated.

Main Results:

  • The MMP-2 -1306 C/T polymorphism showed a significantly higher frequency of the CC genotype (OR = 1.27, 95% CI = 1.10–1.47) and a lower frequency of the CT genotype (OR = 0.78, 95% CI = 0.67–0.91) in breast cancer cases.
  • No significant associations were found for any genotypes of MMP-1, MMP-3, or MMP-9.

Conclusions:

  • The MMP-2 -1306 C/T polymorphism may contribute to breast cancer susceptibility.
  • Further research, particularly in Asian populations, is warranted to confirm these findings.

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