Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exit from naive pluripotency proceeds with variable latency but without asymmetric division to generate population heterogeneity.

Stem cell reports·2026
Same author

A role for Myosin in triggering and executing amnioserosa cell delaminations during dorsal closure.

Scientific reports·2025
Same author

Three Decades of the Spanish Society for Developmental Biology (SEBD): Insights and Emerging Perspectives from the 18th Spanish Society for Developmental Biology Meeting (SEBD 2024).

The International journal of developmental biology·2025
Same author

Polarised cell intercalation during Drosophila axis extension is robust to an orthogonal pull by the invaginating mesoderm.

PLoS biology·2024
Same author

Mechanical stress combines with planar polarised patterning during metaphase to orient embryonic epithelial cell divisions.

Development (Cambridge, England)·2024
Same author

Different temporal requirements for tartan and wingless in the formation of contractile interfaces at compartmental boundaries.

Development (Cambridge, England)·2022

Related Experiment Video

Updated: Jun 6, 2026

Imaging Cell Shape Change in Living Drosophila Embryos
11:20

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

Integrative approaches to morphogenesis: lessons from dorsal closure.

Nicole Gorfinkiel1, Sabine Schamberg, Guy B Blanchard

  • 1Department of Genetics, University of Cambridge, CB2 3EH, Cambridge, United Kingdom. ngorfinkiel@cbm.uam.es

Genesis (New York, N.Y. : 2000)
|December 17, 2010
PubMed
Summary

New multidisciplinary approaches in developmental biology reveal insights into organism formation. Studying Drosophila Dorsal Closure shows how cellular organization drives macroscopic developmental movements.

More Related Videos

Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo
05:51

Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo

Published on: November 10, 2023

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Related Experiment Videos

Last Updated: Jun 6, 2026

Imaging Cell Shape Change in Living Drosophila Embryos
11:20

Imaging Cell Shape Change in Living Drosophila Embryos

Published on: March 30, 2011

Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo
05:51

Monitoring the Mechanical Evolution of Tissue During Neural Tube Closure of Chick Embryo

Published on: November 10, 2023

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

Area of Science:

  • Developmental biology
  • Cellular organization
  • Morphogenesis

Background:

  • Developmental biology traditionally relied on genetic analysis.
  • Recent advances integrate live imaging, image analysis, mechanical perturbation, and modeling.

Purpose of the Study:

  • To illustrate how multidisciplinary approaches yield insights into organism formation.
  • To examine the principles of cellular self-organization during development.

Main Methods:

  • Focus on Dorsal Closure, a key morphogenetic process in Drosophila embryogenesis.
  • Integration of genetic tools with advanced imaging and quantitative analysis.
  • Application of mechanical perturbation and mathematical modeling.

Main Results:

  • Demonstrates how cellular organization, driven by molecular components, leads to macroscopic developmental movements.
  • Provides new and unexpected insights into the mechanisms of organism formation.
  • Highlights the power of interdisciplinary research in developmental biology.

Conclusions:

  • Multidisciplinary approaches are crucial for understanding complex developmental processes.
  • Cellular self-organization is a fundamental principle in the formation of organisms.
  • Drosophila Dorsal Closure serves as a model for studying developmental mechanics.