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Related Experiment Videos

Fulminant viral hepatitis.

E A Fagan1, R Williams

  • 1Liver Unit, King's College Hospital, London.

British Medical Bulletin
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Fulminant viral hepatitis in the UK and US is primarily caused by non-A, non-B hepatitis and hepatitis B. Advances include identifying hepatitis E virus and challenging traditional views on hepatitis A and B pathogenesis.

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Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Fulminant viral hepatitis in the UK and US is mainly attributed to sporadic non-A, non-B hepatitis and hepatitis B.
  • Hepatitis A virus and herpes viruses are uncommon causes of severe hepatitis in these regions.
  • Recent research has identified novel viruses and challenged established understanding of hepatitis pathogenesis.

Purpose of the Study:

  • To review recent advances in understanding the causes and pathogenesis of fulminant viral hepatitis.
  • To highlight the identification of new viral agents implicated in severe hepatitis.
  • To discuss the evolving perspectives on viral replication in fulminant hepatitis.

Main Methods:

  • Identification and cloning of a virus (hepatitis E) associated with enteral non-A, non-B hepatitis.

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  • Detection of virus-like particles resembling togaviridae and flaviviridae in fulminant non-A, non-B hepatitis cases.
  • Application of monoclonal antibody and molecular biology techniques to study viral replication.

    • Main Results:

    • Hepatitis E virus identified as a significant cause of enteral non-A, non-B hepatitis, particularly in pregnant women in endemic areas.
    • Virus-like particles found in some UK patients with fulminant non-A, non-B hepatitis, with potential links to togaviridae and flaviviridae.
    • Evidence suggests active viral replication can persist in fulminant hepatitis A and B, challenging previous assumptions.

    Conclusions:

    • The etiology of fulminant viral hepatitis is diverse, with emerging roles for hepatitis E and other novel viruses.
    • Understanding viral replication mechanisms is crucial for comprehending the pathogenesis of severe hepatitis.
    • Further serological analysis is needed to clarify the role of hepatitis C virus in post-transfusion hepatitis.