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Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...

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Updated: Jun 5, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

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Published on: March 20, 2015

Mixed dimer double-resonance substrates for surface-enhanced Raman spectroscopy.

Mohamad G Banaee1, Kenneth B Crozier

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States. mbanaee@seas.harvard.edu

ACS Nano
|December 18, 2010
PubMed
Summary

This study introduces mixed dimer double-resonance substrates for enhanced Raman spectroscopy. These substrates, using gold nanoparticles of different shapes, significantly boost signal detection for improved analysis.

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Fabrication of polydimethylsiloxane (PDMS)-Based Flexible Surface-Enhanced Raman Scattering (SERS) Substrate for Ultrasensitive Detection
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Fabrication of polydimethylsiloxane (PDMS)-Based Flexible Surface-Enhanced Raman Scattering (SERS) Substrate for Ultrasensitive Detection

Published on: November 17, 2023

Area of Science:

  • Nanotechnology
  • Spectroscopy
  • Materials Science

Background:

  • Surface-enhanced Raman spectroscopy (SERS) relies on plasmonic enhancement.
  • Optimizing plasmon resonances is crucial for maximizing SERS efficiency.
  • Current substrates often offer limited tunability in plasmonic properties.

Purpose of the Study:

  • To investigate mixed dimer double-resonance substrates for SERS.
  • To explore the effect of nanoparticle shape on plasmon resonances in dimers.
  • To compare the enhancement factors of double-resonance substrates with single-resonance ones.

Main Methods:

  • Fabrication and characterization of gold nanoparticle dimers with varying shapes.
  • Experimental measurement of extinction spectra to identify plasmon resonances.
  • Computational simulation of plasmon resonances for mixed dimers.
  • Performance evaluation of double-resonance substrates in SERS.

Main Results:

  • Mixed dimers exhibit two distinct plasmon resonances due to shape asymmetry.
  • These double-resonance structures provide strong field enhancement at both pump and Stokes frequencies.
  • Experimental enhancement factors were quantified and compared to single-resonance substrates.
  • Simulations accurately predicted the plasmon resonances of the mixed dimers.

Conclusions:

  • Mixed dimer double-resonance substrates offer a novel approach to enhance SERS signals.
  • Tailoring nanoparticle shapes in dimers allows for precise control over plasmonic properties.
  • These substrates demonstrate superior performance compared to traditional single-resonance designs.