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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Graves' Disease I: Introduction01:28

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Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
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Related Experiment Video

Updated: Jun 5, 2026

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Recurrent miscarriage and autoimmunity.

Amolak S Bansal1, Banu Bajardeen, Hassan Shehata

  • 1Department of Immunology, St Helier Hospital, Carshalton, Surrey, SM5 1AA, UK. amolak.bansal@esth.nhs.uk

Expert Review of Clinical Immunology
|December 18, 2010
PubMed
Summary

Autoimmunity, including organ-specific and systemic types, is linked to recurrent miscarriage (RM). Research suggests immune cell imbalances, like reduced regulatory T cells, may cause pregnancy loss, guiding future therapies.

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Last Updated: Jun 5, 2026

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05:16

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Published on: August 4, 2021

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11:12

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Published on: April 11, 2019

Area of Science:

  • Immunology
  • Reproductive Medicine

Background:

  • Autoimmunity is associated with recurrent miscarriage (RM).
  • Mechanisms linking autoimmunity to RM are not fully understood.
  • Antiphospholipid antibody syndrome shows prothrombotic and direct trophoblastic inhibitory effects.

Purpose of the Study:

  • To investigate the role of immune system dysregulation in recurrent miscarriage.
  • To explore the connection between T-helper cell profiles and RM.
  • To identify potential therapeutic targets for RM.

Main Methods:

  • Analysis of T-helper cell profiles in women with RM.
  • Assessment of regulatory T cell numbers.
  • Evaluation of Th1 and Th17 subset activity.

Main Results:

  • Women with RM exhibit disturbed T-helper cell profiles.
  • Reduced numbers of regulatory T cells are observed in RM patients.
  • Excessive Th1 and Th17 activity, potentially via natural killer cells, may impact pregnancy.

Conclusions:

  • Autoimmunity is a critical factor to consider in women with recurrent miscarriage.
  • Future therapies for RM may focus on restoring regulatory T cell function.
  • Modulating excessive Th1 and Th17 activity presents a potential therapeutic strategy for RM.