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[Premedication with oral midazolam in children receive sevoflurane general anesthesia]

Xue-ying Jiang1, Tian-zuo Li, Li Li

  • 1Department of Anesthesiology, Capital Medical University, Beijing 100730, China.

Zhonghua Yi Xue Za Zhi
|December 18, 2010
PubMed

Insights

Oral midazolam effectively relieved anxiety in children undergoing anesthesia for cataract surgery. However, it did not reduce emergence agitation, indicating its safety and targeted benefits for perioperative emotional well-being.

Area of Science:

  • Pediatric Anesthesiology
  • Pharmacology
  • Ophthalmology

Background:

  • Preoperative anxiety is common in children undergoing anesthesia.
  • Effective anxiolysis can improve the perioperative experience for pediatric patients.
  • Sevoflurane is a widely used anesthetic agent in pediatric surgery.

Purpose of the Study:

  • To evaluate the efficacy of oral midazolam in managing perioperative anxiety and behavior in children.
  • To assess the impact of midazolam on sedation levels during sevoflurane general anesthesia.
  • To determine if midazolam affects emergence characteristics, such as agitation.

Main Methods:

  • A randomized controlled trial involving 48 children undergoing cataract surgery.
  • Administration of 0.5 mg/kg oral midazolam or placebo 30 minutes prior to anesthesia induction.
  • Assessment of perioperative behavior, emotion, and sedation status.

Main Results:

  • A significantly higher satisfactory sedation ratio was observed in the midazolam group (58.3%) compared to placebo (12.5%).
  • No significant differences were found between groups regarding emergence time, Post-Anesthesia Care Unit (PACU) stay duration, or incidence of emergence agitation.
  • Oral midazolam was found to be safe for use in this pediatric population.

Conclusions:

  • Oral midazolam at a dose of 0.5 mg/kg is a safe premedication for children receiving sevoflurane general anesthesia.
  • Midazolam demonstrates effectiveness in relieving preoperative anxiety in pediatric surgical patients.
  • The study did not find evidence that midazolam reduces the incidence of emergence agitation following sevoflurane anesthesia.
Abstract

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