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Updated: Jun 5, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[Relationship between C-reactive protein gene polymorphaisms and chronic periodontitis]
1Department of Periodontology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Summary
Genetic variations in C-reactive protein (CRP) +1059G/C and +1444C/T were studied in relation to chronic periodontitis. While allele presence affected CRP levels, these specific polymorphisms were not significantly linked to the disease in Han Chinese individuals.
Area of Science:
- Genetics
- Immunology
- Periodontology
Background:
- C-reactive protein (CRP) is an inflammatory marker.
- Genetic polymorphisms in CRP may influence its levels and disease association.
- Chronic periodontitis (CP) is an inflammatory gum disease.
Purpose of the Study:
- To investigate the association between CRP gene polymorphisms (+1444C/T and +1059G/C) and chronic periodontitis (CP) in a Han Chinese population.
- To examine the relationship between these CRP polymorphisms and serum CRP levels.
Main Methods:
- Case-control study involving CP patients (n=126) and healthy controls (n=113).
- Clinical periodontal parameters (attachment loss, probing depth, bleeding on probing) and serum CRP levels were measured.
- Genotyping for CRP +1444C/T and +1059G/C polymorphisms was performed.
Main Results:
- Mean serum CRP levels were significantly higher in the CP group compared to controls (P < 0.001).
- In controls, CRP +1059G/C genotypes influenced serum CRP levels (P < 0.01), and in both groups, CRP +1444C/T genotypes affected CRP levels (P < 0.5).
- No significant differences in allele frequencies or association between CRP polymorphisms and CP were found using regression analysis (P > 0.5).
Conclusions:
- The CRP +1059C allele was linked to lower serum CRP, and the +1444T allele to higher serum CRP.
- However, the CRP +1059G/C and +1444C/T polymorphisms were not significantly associated with chronic periodontitis in this Han Chinese cohort.
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