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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

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Related Experiment Videos

Primary cutaneous anaplastic large-cell lymphoma.

Tracey Newlove1, Aaron Loyd, Rishi Patel

  • 1Department of Dermatology, New York University, New York, NY, USA.

Dermatology Online Journal
|December 18, 2010
PubMed
Summary

Primary cutaneous anaplastic large-cell lymphoma (ALCL) presents as skin nodules or plaques. Diagnosis requires distinguishing it from systemic ALCL, with treatments like radiation or surgery, reserving chemotherapy for advanced cases.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Primary cutaneous anaplastic large-cell lymphoma (ALCL) is a distinct subtype of cutaneous T-cell lymphoma.
  • It typically manifests as solitary or localized skin lesions, such as nodules or plaques.

Observation:

  • Histopathologic examination reveals a diffuse, non-epidermotropic infiltrate.
  • Key features include cohesive sheets of large, anaplastic, CD30-positive tumor cells.

Findings:

  • Distinguishing primary cutaneous ALCL from systemic ALCL with skin involvement and lymphomatoid papulosis is crucial.
  • The characteristic CD30+ large anaplastic cells define this specific cutaneous lymphoma.

Implications:

  • Treatment strategies vary based on disease extent, including clinical monitoring, radiation therapy, and surgical excision.
  • Systemic chemotherapy is generally reserved for cases with disseminated or extracutaneous disease involvement.