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Related Concept Videos

Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
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Published on: March 18, 2014

Eruptive collagenomas.

Priya Batra1, Aaron Loyd, Rishi Patel

  • 1Department of Dermatology, New York University, New York, NY, USA.

Dermatology Online Journal
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

Eruptive collagenomas, a rare skin condition, present as asymptomatic papules composed of collagen. This case highlights a 24-year-old woman with abdominal lesions, emphasizing the persistent nature and unknown cause of these connective-tissue nevi.

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Area of Science:

  • Dermatology
  • Histopathology
  • Connective Tissue Diseases

Background:

  • Connective-tissue nevi are benign hamartomas characterized by abnormal collagen deposition.
  • Eruptive collagenomas represent a rare, acquired variant, typically presenting as sudden-onset papules and nodules.
  • These lesions are histopathologically defined by haphazardly arranged collagen fibers.

Observation:

  • A 24-year-old woman presented with a four-year history of asymptomatic, hypopigmented papules on her abdomen.
  • No familial history of similar cutaneous findings or relevant medical comorbidities were reported.
  • Histopathological examination revealed a connective-tissue nevus predominantly composed of collagen.

Findings:

  • The abdominal papules were confirmed as a connective-tissue nevus, specifically eruptive collagenoma.
  • The lesions exhibited characteristic histopathologic features of haphazardly arranged collagen fibers.
  • The condition was persistent and asymptomatic, with no identified underlying cause.

Implications:

  • This case contributes to the limited understanding of eruptive collagenomas, a rare dermatological condition.
  • The persistent nature of these lesions suggests a need for further research into their pathogenesis.
  • Currently, there are no established therapeutic options for eruptive collagenomas, highlighting a gap in clinical management.