Related Experiment Video
Updated: Jun 5, 2026

Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
Published on: January 12, 2022
Pachydermodactyly
Raegan Hunt1, Rajni Mandal, Ruth Walters
1Department of Dermatology, New York University, New York, NY, USA.
Abstract:
A 16-year-old boy presented to the Pediatric Dermatology Clinic at the Charles C. Harris Skin and Cancer Pavilion with a two-year history of asymptomatic swelling of fingers on both hands. His condition had remained undiagnosed after previous evaluation by several dermatologists and hand specialists. He initially had noticed increased fullness of his proximal left fourth digit. Several months later, he noted swelling of his left fifth digit and right second through fourth digits. The patient reported no pain, pruritus, restriction of movement, morning stiffness, or trauma. He also denied repetitive hand-rubbing movements although his mother stated that he had this habit as a child. Past medical history included allergic rhinitis and asthma. Similar hand findings were not present in any other members of his family.
Related Concept Videos
Desmosomes
Cytoskeletal Linker Proteins - Plakins
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Pleiotropy
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiovascular System Abnormal Findings I: Inspection and Palpation
Abnormal findings observed during an inspection