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Incontinentia pigmenti

Ali Jabbari1, Jonathan Ralston, Julie V Schaffer

  • 1Department of Dermatology, New York University, New York, NY, USA.

Dermatology Online Journal
|December 18, 2010
PubMed

Insights

Incontinentia pigmenti is a genetic skin disorder affecting multiple organs. Early diagnosis in infants, recognizing skin lesions and blood counts, is crucial for preventing vision loss.

Area of Science:

  • Dermatology
  • Genetics
  • Pediatrics

Background:

  • Incontinentia pigmenti (IP) is an X-linked dominant genodermatosis.
  • It affects the skin, teeth, eyes, and central nervous system.

Observation:

  • A case of an infant girl with IP is presented.
  • Cutaneous findings progressed through vesicular, verrucous, and hyperpigmented stages within the first year.
  • Neonatal presentation included linear vesicular lesions, peripheral eosinophilia, and leukocytosis.

Findings:

  • The clinical presentation and laboratory findings can mimic infectious etiologies.
  • Early recognition of characteristic skin lesions and bloodwork aids in diagnosis.

Implications:

  • Prompt diagnosis of Incontinentia pigmenti enables timely ophthalmologic evaluation.
  • Early intervention can help prevent severe visual sequelae in affected infants.

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