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Updated: Jun 5, 2026

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

Efficient Derivation of Retinal Pigment Epithelium Cells from Stem Cells

Published on: March 8, 2015

Incontinentia pigmenti.

Ali Jabbari¹, Jonathan Ralston, Julie V Schaffer

¹Department of Dermatology, New York University, New York, NY, USA.

Dermatology Online Journal

|December 18, 2010

Summary

Incontinentia pigmenti is a genetic skin disorder affecting multiple organs. Early diagnosis in infants, recognizing skin lesions and blood counts, is crucial for preventing vision loss.

Area of Science:

Dermatology
Genetics
Pediatrics

Background:

Incontinentia pigmenti (IP) is an X-linked dominant genodermatosis.
It affects the skin, teeth, eyes, and central nervous system.

Observation:

A case of an infant girl with IP is presented.
Cutaneous findings progressed through vesicular, verrucous, and hyperpigmented stages within the first year.
Neonatal presentation included linear vesicular lesions, peripheral eosinophilia, and leukocytosis.

Findings:

The clinical presentation and laboratory findings can mimic infectious etiologies.
Early recognition of characteristic skin lesions and bloodwork aids in diagnosis.

Implications:

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Prompt diagnosis of Incontinentia pigmenti enables timely ophthalmologic evaluation.

Early intervention can help prevent severe visual sequelae in affected infants.