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Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Pigmentation01:19

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Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
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Epidermal nevus.

Mercedes E Gonzalez1, Ali Jabbari, Brook E Tlougan

  • 1Department of Dermatology, New York University, New York, NY, USA.

Dermatology Online Journal
|December 18, 2010
PubMed
Summary
This summary is machine-generated.

This study describes a rare non-epidermolytic epidermal nevus case in a young man. It highlights the diverse clinical presentations and genetic links of this congenital skin condition.

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Area of Science:

  • Dermatology
  • Genetics
  • Pathology

Background:

  • Epidermal nevi (EN) are congenital skin anomalies.
  • Non-organoid EN lack specific organoid structures and epidermolytic hyperkeratosis.
  • Understanding EN subtypes is crucial for accurate diagnosis and management.

Observation:

  • A case of widespread non-organoid, non-epidermolytic epidermal nevus is presented in a 25-year-old male.
  • Clinical features included hyperpigmented patches, thin plaques along Blaschko lines, psoriasiform plaques on elbows, warty plaques on the trunk, and palmar keratoderma.
  • Histopathologic findings were consistent with the absence of epidermolytic hyperkeratosis.

Findings:

  • Non-organoid EN exhibit varied clinical morphologies and distribution patterns.
  • Histopathology, specifically the presence or absence of epidermolytic hyperkeratosis, is a key differentiator.
  • Syndromal associations are linked to specific genetic mutations underlying EN.

Implications:

  • This case expands the spectrum of clinical presentations for non-organoid EN.
  • Further research into genetic mutations associated with EN subtypes is warranted.
  • Accurate classification of EN aids in predicting potential associated conditions and guiding treatment.